Anti-Candida activity of Tripodanthus acutifolius (Loranthaceae), mechanism of action and toxicity parameters

Autores

  • Valéria Louzada Leal Universidade Federal do Rio Grande do Sul
  • Gabriella da Rosa Monte Machado Universidade Federal do Rio Grande do Sul
  • Mariéle Kliemann Universidade Federal de Ciências da Saúde de Porto Alegre
  • Mario Lettieri Teixeira Instituto Federal Catarinense
  • Rosana de Cássia de Souza Schneider Universidade de Santa Cruz do Sul
  • Chana de Medeiros da Silva Universidade de Santa Cruz do Sul
  • Alexandre Meneghello Fuentefria Universidade Federal do Rio Grande do Sul

DOI:

https://doi.org/10.36560/14620211347

Resumo

The extensive use of azoles antifungals against infections caused by Candida species has been contributing to the selection of resistant strains to this antifungal class, demonstrating that the prospection of new antifungal agents is essential and urgent. Tripodanthus acutifolius (Loranthaceae) is a plant widely used in folk medicine with reported antimicrobial activity. In this context, this study aimed to evaluate the antifungal potential and the mechanisms of action of the crude methanolic extract (CME) of T. acutifolius leaves against Candida species, as well as evaluate their toxicity parameters. As results, the phytochemical characterization of CME suggested the presence of four phenolic compounds as well as a tripodantoside compound. The CME presented minimum inhibitory concentration (MIC) between 16 to 64 μg mL-1, with antifungal action possibly occurring in the fungal cell wall. In addition, the CME showed a synergic effect in combination with fluconazole (FLC). The CME demonstrated no mucosal irritation or tissue damage at all tested concentrations, as well as no cytotoxicity at the MIC values. This study is unprecedented and suggests that T. acutifolius is a new promising source for the development of anti-Candida agents on its own or as chemosensitizer associated to FLC.

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Publicado

2021-07-05

Como Citar

Leal, V. L. ., Machado, G. da R. M., Kliemann, M., Teixeira, M. L. ., Schneider, R. de C. de S. ., Silva, C. de M. da ., & Fuentefria, . A. M. . (2021). Anti-Candida activity of Tripodanthus acutifolius (Loranthaceae), mechanism of action and toxicity parameters. Scientific Electronic Archives, 14(6). https://doi.org/10.36560/14620211347

Edição

v. 14 n. 6 (2021): Scientific Electronic Archives

Seção

Ciências Agrárias

Licença

Copyright (c) 2021 Scientific Electronic Archives

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