Assessing risks and adverse effects of naphazoline hydrochloride: a literature review (2013-2023)

Autores

  • Letícia Apolinário Carlos da Silva Unieuro University Center
  • Mirella Camargo do Nascimento Unieuro University Center
  • Thais Ranielle Souza de Oliveira Unieuro University Center

DOI:

https://doi.org/10.36560/17220241896

Palavras-chave:

Indiscriminate, naphazoline, self-medication, public health.

Resumo

This study examines the risks and harms associated with the use of naphazoline hydrochloride (NHC). The methodology involved a narrative literature review from 2013 to 2023 in Portuguese, English, and Spanish, which identified eleven relevant articles from Scielo, Medline Complete, PubMed, and Google Scholar. The guiding question was: What are the risks and potential adverse effects associated with the use of NHC? Results and Discussion:  Pharmacists play a crucial role in educating against misuse and promoting responsible medication use. However, challenges arise due to the prevalence of self-medication and limited pharmacist involvement in prescribing. The Role of Pharmacists: Harms of Misuse: Key concerns identified include systemic effects, drug-induced rhinitis, and dependence. Overuse of NHC during pregnancy and in children can lead to serious consequences such as hypothermia, bradycardia, and nervous system depression. The abuse hazards of NHC include rebound effects, drug-induced rhinitis, and long-term health risks such as hypertension and heart problems. Conclusion: The study emphasizes the pressing need for enhanced pharmacist training to equip them to effectively counsel and prevent misuse. Additionally, increased public awareness campaigns should be implemented to promote responsible non-prescription healthcare (NHC) use. Stricter dispensing measures, such as regulations to restrict over-the-counter access, should also be put in place. It is essential to promote responsible NHC use. Pharmacists play a critical role in mitigating the risks associated with this widely used medication as public health educators and patient guides.

 

Referências

ANVISA. Anvisa alerta para riscos do uso indiscriminado de medicamentos. Agência Nacional de Vigilância Sanitária, 2021. Available at: <https://www.gov.br/anvisa/pt-br/assuntos/noticias-anvisa/2021/anvisa-alerta-para-riscos-do-uso-indiscriminado-de-medicamentos/20213103_comunicado_ggmon_003_2021.pdf>. Accessed on: Nov 10, 2023.

AZEREDO SOTERIO, K.; ARAÚJO DOS SANTOS, M. A automedicação no Brasil e a importância do farmacêutico na orientação do uso racional de medicamentos de venda livre: uma revisão. Revista da Graduação, [S. l.], v. 9, n. 2, 2016. Available at:<https://revistaseletronicas.pucrs.br/index.php/graduacao/article/view/25673>. Accessed on: Nov 10, 2023.

BORGES, A. S. S.; CARVALHO, C. G.; MAGALHÃES, S. R. Riscos associados ao uso irracional do descongestionante nasal: Cloridrato de nafazolina. Revista Uniabeu, v. 12, n. 31, p. 245-257, 2019. Available atm: <https://revista.uniabeu.edu.br/index.php/RU/article/view/3497>. Accessed on: Nov 10, 2023.

CARDOSO, D. S.; MAGALHÃES, E. Q.; BARROS, L. G.; ALHO, R. da C.; SILVA, A. T. da; OLIVEIRA JUNIOR, J. R. F. de.; RODRIGUES JUNIOR, O. M. O uso indiscriminado de medicamentos isentos de prescrição no Brasil. Research, Society and Development, [S. l.], v. 11, n. 9, p. e26811931503, 2022. DOI: 10.33448/rsd- v11i9.31503. Available at: <https://rsdjournal.org/index.php/rsd/article/view/31503>. Accessed on: Nov 10, 2023..

CONSELHO REGIONAL DE FARMÁCIA DO ESTADO DE SÃO PAULO. Pesquisa aponta que 77% dos brasileiros têm o hábito de se automedicar. CRF-SP, 2019. Available at: <https://www.crfsp.org.br/noticias/10535-pesquisa-aponta-que-77-dos-brasileiros-tem-o-habito-de-se-automedicar.html>. Accessed on: Nov 10, 2023.

DÍAZ, Mariano et al. Intoxicación grave com nafazolina: puesta al día a partir de um error terapéutico. Archivos Argentinos de Pediatría, Buenos Aires, v. 116, n. 4, p. 626-629, ago. 2018. Available at: <http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-00752018000400031>. Accessed on: Nov 10, 2023.

DIONIZIO, A.: I. et al. A DEPENDÊNCIA DE DESCONGESTIONANTES NASAIS E SEUS EFEITOS COLATERAIS. Available at <https://multivix.edu.br/wp-content/uploads/2021/05/revista-esfera-saude-v05-n02-artigo02.pdf>. Accessed on: Nov 10, 2023.

LIMA, M. I. M. de M.; SILVA, J. M.; SIQUEIRA, L. da P. Riscos Associados à automedicação do Cloridrato de Nafazolina e o farmacêutico como protagonista para o uso racional de medicamentos. Research, Society and Development, [S. l.], v.10, n. 15, p. e323101522935, 2021. DOI: 10.33448/rsd-v10i15.22935. Available at: <https://rsdjournal.org/index.php/rsd/article/view/22935>. Accessed on: Nov 10, 2023.

MARTINS, Thulio Ramos et al. Os riscos causados pelo uso indiscriminado de descongestionantes nasais derivados da nafazolina. Revista Multidisciplinar do Nordeste Mineiro, Teófilo Otoni, v. 1, n. 1, p. 1-13, set. 2022. Available at: <https://revistas.unipacto.com.br/storage/publicacoes/2022/1097_os_riscos_causados_pelo_uso_indiscriminado_de_descongestionantes_nasai.pdf>. Accessed on: Nov 10, 2023.

QUEIROZ, Thaynná Cordeiro et al. Uso de Cloridrato de Nafazolina em pacientes gestantes e seus malefícios para o binômio: Use of Naphazoline Hydrochloride in pregnant patients and its harm to the binomial. CPAH Science Journal of Health, [S. l.], v. 5, n. 2, 2022. DOI: 10.56238/cpahjournalv5n2-010. Available at: <https://cpahjournal.com/cpah/article/view/133>. Accessed on: Nov 10, 2023.

RODRIGUES, C. E.; PILOTO, J. A. D. R.; TIYO, R. Rinite medicamentosa e o consumo indiscriminado de vasoconstritores nasais tópicos. Uningá Review, [S. l.],v. 29, n. 1, 2017. Available at: <https://revista.uninga.br/uningareviews/article/view/1918>. Accessed on: Nov 10, 2023.

ROTHER, E. T. Revisão sistemática X revisão narrativa. Acta Paulista de Enfermagem, v. 20, n. 2, p. v–vi, 2007. Available at: <https://www.scielo.br/j/ape/a/z7zZ4Z4GwYV6FR7S9FHTByr/?lang=pt>. Accessed on: Nov 10, 2023.

THOMSETH, V. et al. Exposure to antazoline-naphazoline eye drops during pregnancy and the risk of congenital malformations: a Danish nationwide cohort study. Acta ophthalmologica, v. 97, n. 5, p. 505–509, 2019a. Available at: https://pubmed.ncbi.nlm.nih.gov/30479070/. Accessed on: Nov 10, 2023.

U.S. FOOD & DRUG ADMINISTRATION. Comunicado de la FDA sobre la seguridade de los medicamentos: Sucesos adversos graves resultantes de ingestión acidental por niños de colírios (gotas para los ojos) y aerosoles nasales de venta libre. U.S. Food & Drug Administration, 2016. Available at: <https://www.fda.gov/drugs/drug-safety-and-availability/comunicado-de-la-fda-sobre-la-seguridad-de-los-medicamentos-sucesos-adversos-graves-resultantes-de>. Accessed on: Nov 10, 2023.

Publicado

2024-02-29

Como Citar

Silva, L. A. C. da ., Nascimento , M. C. do, & Oliveira, T. R. S. de. (2024). Assessing risks and adverse effects of naphazoline hydrochloride: a literature review (2013-2023). Scientific Electronic Archives, 17(2). https://doi.org/10.36560/17220241896