Effects of pharmacology with acepromazine maleate in tranquilization, hematology and vital parameters in cats


  • L. F. Tannus
  • D. Eurides
  • E. D. Mundim
  • V. A. Mundim
  • G. P. Eurides
  • R. B. K. Vieira




Yintang, clinical safety, underdosing


This work aims to evaluate the tranquilization, the hematological and the physiological parameters of domestic cats undergoing pharmacupuncture with acepromazine maleate. Seven animals received 5% of the dose of the drug indicated for this species in acupoint Yintang (GI) and seven (GII) received the same dose intramuscularly. The reassurance was assessed using a scale adapted from Dobbins et al. (2002). The GI group demonstrated that 71.43% of the animals presented drowsiness and projection of the third eyelid and 28.47% were less active. In GII group, 14.28% of cats were less active and 85.72% demonstrated were unchanged. About the hematologicals changing, the two groups demonstrated a slight increase of leukocytes, in GI decreased hematocrit and erythrocytes. According to physiological parameters, GI presented decrease rectal temperature and increase in respiratory rate. There were no significant changes on the heart rate and systolic blood pressure in any cat. In GII, occurred a decrease in diastolic blood pressure. The pharmacupunture showed effectiveness in cats tranquilization, besides clinical safety.


ALTMAN, S. Acupuncture therapy in small animal practice. The compendium in continuing education. v.19, n.11, p.1233- 45, 1997.

ALVARENGA, M.A.; FERREIRA, J.C.P.; MEIRA, C.; LUNA, S.P.L.; BURNS, P.J. Induction of luteolysis in mares utilizing a micro-dose of prostaglandin F2 alfa in the sacral lumbar space. Journal of Equine Veterinary Science, v.18, n.3, p.167-16, 1998.

BREARLEY, J.C. Sedation, premedication and analgesia. In: HALL, L.W.; TAYLOR, P.M. Anaesthesia of the cat. London: Baillière Tindall, 1994. p.111-128.

BLUMER, E. A review of the use selected neuroleptic drugs in the management of nondomestic hoofstock. Proccedings American Association of Veterinarians, 1991. p.333-339.

BROCK, N. Acepromazine revised. Canadian Journal of Veterinary Research, v.35, n.6, p.458-459, 1994.

COLBY, E.D.; SANFORD, T.D. Blood pressure and heart and respiratory rates of cats under ketamine/acepromazine anesthesia. Feline Practice, v.11, n.5, p.19-24, 1981.

CORTOPASSI, S.R.G.; FANTONI, D.T. Medicação pré-anestésica. In: FANTONI, D.T., CORTOPASSI, S.R. Anestesia em cães e gatos. 2.ed. São Paulo: Roca, 2009. Cap. 13, p.151-158.

EURIDES, D.; RAISER, A.G.; PIPPI, NL.; KURTZ, S.O.; FIALHO, S.A.G. A influência do maleato de acepromazina sobre o hemograma de cães. Revista Ciência Rural, v.11, n.2-3, p.111-114, 1981.

EURIDES, D.; RAISER, A.G.; FIALHO, S.A.G. Efeitos do maleato de acepromazina, em doses elevadas, na tranquilização de cães. Revista Ciência Rural, v.1, n.2-3, p.105-110, 1987.

FANTONI, D.T.; CORTOPASSI, S.R.G.; BERNARDI, M.M. Anestésicos intravenosos e outros parenterais. In: SPINOSA, H.S.; GÓRNIAK, S.L.; BERNARDI, M.M. Farmacologia aplicada à medicina veterinária. Rio de Janeiro: Guanabara Koogan, 1999. p.114-124.

FANTONI, D.T. Recuperação pós-anestésica. In: FANTONI, D.T.; CORTOPASSI, S.R.G. Anestesia em cães e gatos. São Paulo: Roca, 2002, p.369-372.

FANTONI, D.T. Medicação pré-Anestésica. In: FANTONI, D.T.; CORTOPASSI, S.R.G. Anestesia em cães e gatos. São Paulo: Roca, 2009. Cap.13, p.151- 158.

FARIA, A.B.; SCOGNAMILLO-SZABÓ, M.V.R. Acupuntura veterinária: conceitos e técnicas . Revisão. Ars Veterinária, v.24, n.2, p.83-91, 2008.

FEITOSA, F.L.F. Exame físico geral ou de rotina. In: FEITOSA, F.L.F. Semiologia veterinária a arte do diagnóstico. Roca: São Paulo. 2004. p.77-102.

HALL, L.W.; CLARKE, K.H.; TRIM, C.M. Anaesthesia of the pig. In: Veterinary anaesthesia. 10.ed. London: Saunders, 2001. Cap.14, p.367-383.

LEMKE, K.A. Anticholinergics and Sedatives. In: TRANQUILLI, W.J.; THURNON, J.C.; GRIMM, K.A. Veterinary Anesthesia and Analgesia. 4.ed. Iowa: Blackwell Publishing, 2007.p.203-240.

LUNA, S.P.; ANGELI, A.L.; FERIERRA, C.L.; LETTRY, V.; SCOGNAMILLOSZABÓ, M. Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses. Evidence-Based Complementary and Alternative Medicine, v.5, n.3, p.267-272, 2008.

MASSONE, F. Medicação pré-anestésica. In: MASSONE, F. Anestesiologia veterinária. 3.ed. Guanabara Koogan: Rio de Janeiro, 1999. 17p.

MASSONE, F. Anestesiologia veterinária – Farmacologia e técnicas. 4.ed. Rio de Janeiro: Guanabara Koogan, 2003. 326p.

MELLO, J.R.B; CASTRO JUNIOR, J.F.; SILVA FILHO, A.P.F. Resposta hematológica, respiratória e cardiocirculatória de equinos submetidos a três protocolos de indução anestésica. Brazilian Journal Veterinary Animal. Science, v.37, n.6. São Paulo, 2000.

MUIR, W.W.; HUBBELL, J.A.E. Equine anesthesia. St Louis: Mosby-Year Book. Cap.11, 1991. p.247-280.

MUIR, W.W.; HUBBEL, J.A.E. Manual de anestesia veterinária. 3.ed. Porto Alegre: Artmed, 2001. p.31-44.

PASCOE, P.J. The case for the routine use of analgesics. Veterinary Clinics of North America: Small Animal Practice, v.22, p.357-359, 1992.

SIEGEL, S. Estatística não-paramétrica, para as ciências do comportamento. São Paulo: McGraw-Hill do Brasil, 1975. 350 p.

SPINOSA, H.S.; GORNIAK, S.L.; BRENARDI, M.M. Tranquilizantes e Relaxantes Musculares de Ação Central. In: Farmacologia aplicada à medicina veterinária. Rio de Janeiro: Guanabara Koogan, 1996. Cap.14, p.131-139.

STEFFEY, E.P.; WHEAT, J.D.; MEAGHER, D.M.; NORRIE, R.D.; MCKEE, J.; BROWN, M.; ARNOLD, J. Body position and mode of ventilation influences arterial pH oxygen and carbon dioxid tension in halothane-anesthetised horses. American Journal of Veterinary Research, v.38, n.3, p.379-382, 1997.

WANG, X.L.; ZHANG, T.F.; ZHANG, H.X.; MAO, H.R.; HUANG, G.F. Therapeutic effects of acupoint injection at cervical Jiaji points and effects on ET and CGRP in the patient of ischemic stroke. Zhongguo Zhen Jiu, v.27, n.2, p.93-5, 2007.

WILSON, D.V.; EVANS, A.T.; CARPENTER,R.A.; MULLINEAUX,D.R. The effect of four anesthetic protocols on splenic size in dogs. Veterinary Anesthesia and Analgesia, v.31, n.2, p.102-108, 2004.

WYNN, S.G.; LUNA, S.P.L.; LIU, H.; XIE, H.; NAN, T.C.; CHIEN, C.H. Global acupuncture research: previously untranslated studies. Studies from Brazil. In: SCHOEN, A. M. (Ed.). Veterinary acupuncture: ancient art to modern medicine. St. Louis: Mosby, 2001. p.53-57.

XIE, H.; PREAST, V. Xie’s veterinary acupuncture. 0xford: Blackwell Publishing, 2007. 376p.

ZHOU, W.; FU, L.W.; TJEN-A-LOOI, S.C.; LI, P.; LONGHURST, J.C. Afferent mechanisms underlying stimulation modality related modulation of acupuncture-related cardiovascular responses. Journal of Applied Physiology, v.98, n.3, p.872-80, 2005.




Como Citar

Tannus, L. F., Eurides, D., Mundim, E. D., Mundim, V. A., Eurides, G. P., & Vieira, R. B. K. (2015). Effects of pharmacology with acepromazine maleate in tranquilization, hematology and vital parameters in cats. Scientific Electronic Archives, 9(1), 45–49. https://doi.org/10.36560/912016223

Artigos mais lidos pelo mesmo(s) autor(es)