@article{Magalhães_Menezes Filho_Ventura_Batista-Ventura_Castro_Porfiro_2021, title={Chemical profile and antioxidant, antibacterial, and cytotoxic activities on Artemia salina from the essential oil of leaves and xylopodium of Cochlospermum regium}, volume={15}, url={https://sea.ufr.edu.br/SEA/article/view/1506}, DOI={10.36560/15120221506}, abstractNote={<p><em>Cochlospermum regium</em> is a shrub plant species from the Cerrado domain used in traditional medicine. This study aimed to evaluate the chemical profile and antioxidant, antibacterial and cytotoxic activities on <em>Artemia salina</em> from the essential oil of fresh leaves and xylopodium. Fresch leaves and xylopodium of <em>C. regium</em> were collected in an area of ​​Cerrado domain in Goiás State, Brazil, 2021. The essential oil was obtained by hydrodistillation, the yield was quantified and the chemical profile determined by gas chromatography with mass spectrometry (GC-MS). Physicochemical analyzes were carried out for organoleptic analysis (color and appearance), solubility, relative density (g mL<sup>-1</sup>), refractive index, optical rotation (α<sub>D</sub>), antioxidant activity in DPPH radical reduction (IC<sub>50</sub> µL mL<sup>-1</sup>), antibacterial activity on <em>Escherichia coli</em>, <em>Staphylococcus aureus</em>, <em>Enterococcus faecalis</em>, <em>Salmonella serovar</em> Enteritidis and <em>Salmonella serovar</em> Thyphymurium by the disc method (mm), and cytotoxicity bioassay on <em>Artemia salina</em> (LC<sub>50</sub> µg mL<sup>-1</sup>). The major compounds for the essential oil of fresh leaves were viridiflorol 10.21%, Copaen-4-α-ol <β>, longiborneol 9.07 and β-bisabolene 11.48%, and for the essential oil of xylopodium β-selinene 26.17%, aromadendrene 8.66 % and thujopsene 8.09%. The yield was 0.58 and 0.33%, color slightly yellow and yellow for fresh leaves and xylopodium, respectively. Positive solubility, refractive index of 1.3468 and 1.3347, optical rotation +48.8 and +21.5, relative density 0.932 and 0.936 g mL<sup>-1</sup>, antioxidant activity IC<sub>50</sub> = 47.65 and 111.16 µL mL<sup>-1</sup> for fresh leaves essential oil and xylopodium, respectively. The essential oil from fresh leaves showed high antibacterial potential for all strains, as well as for cytotoxic activity on <em>A. salina</em> with LC<sub>50</sub> = 90.17 and 625.08 µg mL<sup>-1</sup>, respectively.</p>}, number={1}, journal={Scientific Electronic Archives}, author={Magalhães, Roberta Heloísa de Paula and Menezes Filho, Antonio Carlos Pereira de and Ventura, Matheus Vinicius Abadia and Batista-Ventura, Hellen Regina Fernandes and Castro, Carlos Frederico de Souza and Porfiro, Cinthia Alves}, year={2021}, month={dez.} }