Clinical and epidemiological profile of breast cancer patients diagnosed in Sinop – MT: A descriptive study

Autores

  • A. E. F. Chiaradia Universidade Federal de Mato Grosso
  • K. A. S. Ferreira Universidade Federal de Mato Grosso
  • T. C. Medeiros Universidade Federal de Mato Grosso
  • E. F. O Mota Universidade Federal de Mato Grosso
  • R. A. R. Universidade Federal de Mato Grosso
  • A. Guimarães Universidade Federal de Mato Grosso
  • D. A. Queiroz Universidade Federal de Mato Grosso
  • A. Rossini Hospital Santo Antônio
  • E. F. Silveira Hospital Santo Antônio
  • P. Alegranci Universidade Federal de Mato Grosso
  • E. A. I. F. Queiroz Universidade Federal de Mato Grosso

DOI:

https://doi.org/10.36560/14320211327

Palavras-chave:

Cancer, Breast cancer, Overweight, Obesity, Prognosis.

Resumo

Breast cancer is a multifactorial disease that have been increasing in an alarm rate worldwide, and has overweight and obesity as important risk factors, being considered a significant public health problem. The present study aimed to demonstrate the clinical and epidemiological profile of breast cancer patients diagnosed in Sinop-MT (Brazil) and analyze the prevalence of overweight and obesity in these patients. This is a descriptive study, with data collected by analysis of patient’s medical records who were diagnosed with breast carcinoma in the Department of Oncology of Santo Antônio’s Hospital. Data were tabulated and analyzed in an Excel® spreadsheet software (Office 365), with a descriptive analysis in percentage. Results demonstrated that 100% of patients were women; 85.7% were affected by ductal and/or lobular breast carcinomas; all deaths occurred in patients over 40 years and 75% of deaths occurred in advanced stages; being 68.75% of the most severe cases’ stages present in the oldest patients. Furthermore, it was observed that 37.12% of the patients were classified as overweight or obese, 88.57% were treated with chemotherapy and 91.44% treated with combined therapies. In conclusion, it was observed that a great number of breast cancer patients were overweight/obese, presented ductal and lobular carcinoma, the deaths occurred predominantly in the over forty years and were related with the presence of metastasis and advanced stage.

Referências

ABREU, E.; KOIFMAN, S. Fatores prognósticos no câncer de mama feminino. Revista Brasileira de Cancerologia, [S. l.], v. 48, n. 01, p. 113–131, 2002.

ALBRECHT, CAM; AMORIM, MHC; ZANDONADE, E.; VIANA, K.; CALHEIROS, JO. Breast cancer mortality among patients attending a cancer hospital, Vitoria, ES. Revista Brasileira de Epidemiologia, [S. l.], v. 16, n. 3, p. 582–591, 2013.

ARGILÉS, JM; STEMMLER, B.; LÓPEZ-SORIANO, FJ; BUSQUETS, S. Inter-tissue communication in cancer cachexia. Nature Reviews Endocrinology, [S. l.], v. 15, n. 1, p. 9–20, 2018. DOI: 10.1038/s41574-018-0123-0.

AUTIER, Philippe; BONIOL, Mathieu; LAVECCHIA, Carlo; VATTEN, Lars; GAVIN, Anna; HÉRY, Clarisse; HEANUE, Mary. Disparities in breast cancer mortality trends between 30 European countries: Retrospective trend analysis of WHO mortality database. BMJ (Online), [S. l.], v. 341, n. 7768, p. 335, 2010. DOI: 10.1136/bmj.c3620.

AVGERINOS, Konstantinos I.; SPYROU, Nikolaos; MANTZOROS, Christos S.; DALAMAGA, Maria. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism: Clinical and Experimental, [S. l.], v. 92, p. 121–135, 2019. DOI: 10.1016/j.metabol.2018.11.001.

BARROS, LO; MENEZES, VBB; JORGE, AC; MORAIS, SSF; SILVA, MGC. Mortalidade por Câncer de Mama: uma Análise da Tendência no Ceará, Nordeste e Brasil de 2005 a 2015. Revista Brasileira de Cancerologia, [S. l.], v. 66, p. e-14740, 2020.

BERGMAN, Liesbeth; DEKKER, Gert; VAN KERKHOFF, Elly HM; PETERSE, Hans L.; VAN DONGEN, Johannes A.; VAN LEEUWEN, Flora E. Influence of age and comorbidity on treatment choice and survival in elderly patients with breast cancer. Breast Cancer Research and Treatment, [S. l.], v. 18, n. 3, p. 189–198, 1991. DOI: 10.1007/BF01990035.

BRUM, Igor Vilela; GUERRA, Maximiliano Ribeiro; CINTRA, Jane Rocha Duarte; BUSTAMANTE-TEIXEIRA, Maria Teresa. Câncer de mama metastático: Aspectos clinicopatológicos e sobrevida segundo o sítio de metástase. Medicina (Brazil), [S. l.], v. 50, n. 3, p. 158–168, 2017. DOI: 10.11606/issn.2176-7262.v50i3p158-168.

CALLE, Eugenia E.; KAAKS, Rudolf. Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms. Nature Reviews Cancer, [S. l.], v. 4, n. 8, p. 579–591, 2004. DOI: 10.1038/nrc1408.

COMIRAN, Patrícia K. et al. Botryosphaeran Attenuates Tumor Development and the Cancer Cachexia Syndrome in Walker-256 Tumor-Bearing Obese Rats and Improves the Metabolic and Hematological Profiles of These Rats. Nutrition and Cancer, [S. l.], p. 1–18, 2020. DOI: 10.1080/01635581.2020.1789681.

DE FREITAS JÚNIOR, Ruffo; NUNES, Rodrigo Disconzi; MARTINS, Edesio; CURADO, Maria Paula; FREITAS, Nilceana Maya Aires; SOARES, Leonardo Ribeiro; OLIVEIRA, José Carlos. Fatores prognósticos do câncer de mama e sobrevida global em cinco e dez anos na cidade de Goiânia, Brasil: Estudo de base populacional. Revista do Colegio Brasileiro de Cirurgioes, [S. l.], v. 44, n. 5, p. 435–443, 2017. DOI: 10.1590/0100-69912017005003.

DIETZE, Eric C.; CHAVEZ, Tanya A.; SEEWALDT, Victoria L. Obesity and Triple-Negative Breast Cancer: Disparities, Controversies, and Biology. American Journal of Pathology, [S. l.], v. 188, n. 2, p. 280–290, 2018. DOI: 10.1016/j.ajpath.2017.09.018.

FAYER, VA; GUERRA, MR; CINTRA, JRD; BUSTAMANTE-TEIXEIRA, MT. Ten-year survival and prognostic factors for breast cancer in the southeast region of Brazil. Revista Brasileira de Epidemiologia, [S. l.], v. 19, n. 4, p. 766- 778., 2016.

GALLAGHER, Emily Jane; LEROITH, Derek. Obesity and diabetes: The increased risk of cancer and cancer-related mortality. Physiological Reviews, [S. l.], v. 95, n. 3, p. 727–748, 2015. DOI: 10.1152/physrev.00030.2014.

GODINHO, Eduardo Rodrigues; KOCH, Hilton Augusto. Rastreamento do câncer de mama: aspectos relacionados ao médico. Radiologia Brasileira, [S. l.], v. 37, n. 2, p. 91–99, 2004. DOI: 10.1590/s0100-39842004000200006.

GUEDES, Juliana Barroso Rodrigues; GUERRA, Maximiliano Ribeiro; ALVIM, Mariana Macedo; LEITE, Isabel Cristina Gonçalves. Fatores associados à adesão e à persistência na hormonioterapia em mulheres com câncer de mama. Revista Brasileira de Epidemiologia, [S. l.], v. 20, n. 4, p. 636–649, 2017. DOI: 10.1590/1980-5497201700040007.

HOWLADER, Nadia; CRONIN, Kathleen A.; KURIAN, Allison W.; ANDRIDGE, Rebecca. Differences in breast cancer survival by molecular subtypes in the United States. Cancer Epidemiology Biomarkers and Prevention, [S. l.], v. 27, n. 6, p. 619–626, 2018. DOI: 10.1158/1055-9965.EPI-17-0627.

HURSTING, Stephen D.; HURSTING, Marcie J. Growth signals, inflammation, and vascular perturbations: Mechanistic links between obesity, metabolic syndrome, and cancer. Arteriosclerosis, Thrombosis, and Vascular Biology, [S. l.], v. 32, n. 8, p. 1766–1770, 2012. DOI: 10.1161/ATVBAHA.111.241927.

IACOVIELLO, Licia; BONACCIO, Marialaura; DE GAETANO, Giovanni; DONATI, Maria Benedetta. Epidemiology of breast cancer, a paradigm of the “common soil†hypothesis. Seminars in Cancer Biology, [S. l.], v. S1044-579X, n. 20, p. 30043–30052, 2020. DOI: 10.1016/j.semcancer.2020.02.010.

IBGE. 2020. Disponível em: https://www.ibge.gov.br/cidades-e-estados/mt/sinop.html. Acesso em: 22 jan. 2021.

IBGE. 2021. Disponível em: https://cidades.ibge.gov.br/brasil/mt/sinop/historico. Acesso em: 25 jan. 2021.

INCA. 2020. Disponível em: https://www.inca.gov.br/estimativa. Acesso em: 22 jan. 2021.

JONES, Stephen E. et al. Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer. Journal of Clinical Oncology, [S. l.], v. 24, n. 34, p. 5381–5387, 2006. DOI: 10.1200/JCO.2006.06.5391.

JUNG, Un Ju; CHOI, Myung Sook. Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. International Journal of Molecular Sciences, [S. l.], v. 15, n. 4, p. 6184–6223, 2014. DOI: 10.3390/ijms15046184.

LOUWMAN, W. J.; JANSSEN-HEIJNEN, M. L. G.; HOUTERMAN, S.; VOOGD, A. C.; VAN DER SANGEN, M. J. C.; NIEUWENHUIJZEN, G. A. P.; COEBERGH, J. W. W. Less extensive treatment and inferior prognosis for breast cancer patient with comorbidity: A population-based study. European Journal of Cancer, [S. l.], v. 41, n. 5, p. 779–785, 2005. DOI: 10.1016/j.ejca.2004.12.025.

MARTINS, Karine Anusca; FREITAS-JUNIOR, Ruffo; MONEGO, Estelamaris Tronco; PAULINELLI, Régis Resende. Antropometria e perfil lipídico em mulheres com câncer de mama: Um estudo caso-controle. Revista do Colegio Brasileiro de Cirurgioes, [S. l.], v. 39, n. 5, p. 358–363, 2012. DOI: 10.1590/S0100-69912012000500003.

MUNHOZ, MP; LEMOS, AG; GONÇALVES, RD; ANJOS, JC; LOPES, JF; CELEMI, LG. INCIDÊNCIA DE ESTEATOSE HEPÃTICA GORDUROSA NÃO ALCÓOLICA NA POPULAÇÃO ADULTA ATUAL INCIDENCE OF NON-ALCOHOLIC GREASY FATAL ESTEATOSIS IN THE CURRENT ADULT POPULATION. Revista Saúde UniToledo, [S. l.], v. 1, n. 2, p. 110–123, 2017.

OSÓRIO-COSTA, Felipe; ROCHA, Guilherme Z.; DIAS, Marília M.; CARVALHEIRA, José B. C. Mecanismos epidemiológicos e moleculares que associam obesidade e câncer. Arquivos Brasileiros de Endocrinologia e Metabologia, [S. l.], v. 53, n. 2, p. 213–226, 2009. DOI: 10.1590/S0004-27302009000200013.

PEARSON-STUTTARD, Jonathan; ZHOU, Bin; KONTIS, Vasilis; BENTHAM, James; GUNTER, Marc J.; EZZATI, Majid. Retraction: Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment (The lancet. Diabetes & endocrinology (2018) 6 6 (437) PII: S2213-8587(17)30366-2). The lancet. Diabetes & endocrinology, [S. l.], v. 6, n. 2, p. 95–104, 2018. DOI: 10.1016/S2213-8587(17)30366-2.

PERES, Val�ria Costa; VELOSO, Danyelle Lorrane Carneiro; XAVIER, Raphaela Maioni; SALGE, Ana Karina Marques; GUIMARÿ½ES, Jana�na Valadares. Câncer de mama em mulheres: Recidiva e sobrevida em cinco anos. Texto e Contexto Enfermagem, [S. l.], v. 24, n. 3, p. 740–747, 2015. DOI: 10.1590/0104-07072015000600014.

POLLAK, Michael. The insulin and insulin-like growth factor receptor family in neoplasia: An update. Nature Reviews Cancer, [S. l.], v. 12, n. 3, p. 159–169, 2012. DOI: 10.1038/nrc3215.

QUEIROZ, Eveline A. I. F.; AKAMINE, Eliana H.; CARVALHO, Maria Helena C.; SAMPAIO, Sandra C.; FORTES, Zuleica B. Metformin reduces the Walker-256 tumor development in obese-MSG rats via AMPK and FOXO3a. Life Sciences, [S. l.], v. 121, p. 78–87, 2015. DOI: 10.1016/j.lfs.2014.11.028.

ROCHA, Marina Elias et al. Câncer de mama: caracterização quanto a idade e aos aspectos tumorais (tipo de tumor e extensão). Brazilian Journal of Development, [S. l.], v. 6, n. 1, p. 2375–2387, 2020. DOI: 10.34117/bjdv6n1-175.

RODRIGUES, Juliana Dantas; CRUZ, Mércia Santos; PAIXÃO, Adriano Nascimento. Uma análise da prevenção do câncer de mama no Brasil. Ciencia e Saude Coletiva, [S. l.], v. 20, n. 10, p. 3163–3176, 2015. DOI: 10.1590/1413-812320152010.20822014.

ROJAS, Kristin; STUCKEY, Ashley. Breast Cancer Epidemiology and Risk Factors. Clinical Obstetrics and Gynecology, [S. l.], v. 59, n. 4, p. 651–672, 2016. DOI: 10.1097/GRF.0000000000000239.

SATARIANO, William A.; RAGLAND, David R. The effect of comorbidity on 3-year survival of women with primary breast cancer. Annals of Internal Medicine, [S. l.], v. 120, n. 2, p. 104–110, 1994. DOI: 10.7326/0003-4819-120-2-199401150-00002.

SIEGEL, Rebecca et al. Cancer treatment and survivorship statistics, 2012. CA: A Cancer Journal for Clinicians, [S. l.], v. 62, n. 4, p. 220–241, 2012. DOI: 10.3322/caac.21149.

SILVA, Amadeu Z. et al. Botryosphaeran reduces obesity, hepatic steatosis, dyslipidaemia, insulin resistance and glucose intolerance in diet-induced obese rats. Life Sciences, [S. l.], v. 211, p. 147–156, 2018. DOI: 10.1016/j.lfs.2018.09.027.

SOARES, Priscila Bernardina M.; FILHO, Sidinei Quirino; DE SOUZA, William Pereira; GONÇALVES, Renata Cristina R.; MARTELLI, Daniella Reis B.; SILVEIRA, Marise Fagundes; MARTELLI JÚNIOR, Hercílio. Características das mulheres com câncer de mama assistidas em serviços de referência do Norte de Minas Gerais. Revista Brasileira de Epidemiologia, [S. l.], v. 15, n. 3, p. 595–604, 2012. DOI: 10.1590/S1415-790X2012000300013.

SOLER, Gisele Lima Nogueira; SILVA, Albert Wilson Santos Machado; SILVA, Valéria Cataldo Gomes Da; TEIXEIRA, Rosimeire de Jesus. Doença hepática gordurosa não-alcoólica: associação com síndrome metabólica e fatores de risco cardiovascular. Rev. SOCERJ, [S. l.], v. 21, p. 94–100, 2008.

STARK, A.; STAHL, M. S.; KIRCHNER, H. L.; KRUM, S.; PRICHARD, J.; EVANS, J. Body mass index at the time of diagnosis and the risk of advanced stages and poorly differentiated cancers of the breast: Findings from a case-series study. International Journal of Obesity, [S. l.], v. 34, n. 9, p. 1381–1386, 2010. DOI: 10.1038/ijo.2010.69.

TANG, Yuan; WANG, Yue; KIANI, Mohammad F.; WANG, Bin. Classification, Treatment Strategy, and Associated Drug Resistance in Breast CancerClinical Breast CancerElsevier Inc., , 2016. DOI: 10.1016/j.clbc.2016.05.012.

WHO. 2021a. Disponível em: https://www.who.int/health-topics/cancer#tab=tab_1. Acesso em: 22 jan. 2021.

WHO. 2021b. Disponível em: https://www.who.int/health-topics/obesity#tab=tab_1. Acesso em: 22 jan. 2021.

YANCIK, Rosemary; WESLEY, Margaret N.; RIES, Lynn A. G.; HAVLIK, Richard J.; EDWARDS, Brenda K.; YATES, Jerome W. Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. Journal of the American Medical Association, [S. l.], v. 285, n. 7, p. 885–892, 2001. DOI: 10.1001/jama.285.7.885.

Downloads

Publicado

2021-06-30

Como Citar

Chiaradia, A. E. F. ., Ferreira, K. A. S. ., Medeiros, T. C. ., Mota, E. F. O., Siviero, R. A. R. ., Guimarães, A., Queiroz, D. A., Rossini, A., Silveira, E. F., Alegranci, P., & Queiroz, E. A. I. F. . (2021). Clinical and epidemiological profile of breast cancer patients diagnosed in Sinop – MT: A descriptive study. Scientific Electronic Archives, 14(3), 84–93. https://doi.org/10.36560/14320211327

Edição

v. 14 n. 3 (2021): Scientific Electronic Archives

Seção

Ciências da Saúde

Licença

Copyright (c) 2021 Scientific Electronic Archives

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

A revista se reserva o direito de fazer alterações nas regras originais, na ortografia e na ordem gramatical, a fim de manter o idioma de culto padrão, respeitando, no entanto, o estilo dos autores. Os artigos publicados são de propriedade da revista Scientific Electronic Archives, tornando-se sua reimpressão total ou parcial, sujeitos à autorização expressa da direção da revista. A fonte original da publicação deve ser mantida. Os originais não serão devolvidos aos autores. As opiniões expressas pelos autores dos artigos são de sua exclusiva responsabilidade.

The journal reserves the right to make changes to the original rules, spelling and grammatical order, in order to keep the language of worship default, respecting, however, the style of the authors. Articles published are the property of Scientific Electronic Archives magazine, becoming its total or partial reprint, subject to the express authorization of the direction of the journal. The original source of publication should be retained. The originals will not be returned to the authors. Opinions expressed by authors of articles are solely your responsibility.

Licença Creative Commons
This journal uses the License  Creative Commons Atribuição 4.0 Internacional.