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Ciências da Saúde
Publicado: 2018-11-13

Effect of early physiotherapy on neuroglial interaction after injury to the motor cortex

Federal University of Mato Grosso - Campus Sinop, Brazil

R. C. A. Berber

Institute of Health Sciences, Animal Physiology


The term cerebral plasticity covers the possible mechanisms of neuronal reorganization, recruitment of functionally homologous pathways, synaptogenesis, dendritic arborization and activation of secondary areas. Cerebral reorganization still begins in the acute phase after the cortical lesion, with progressive improvement until the stabilization of the condition. Although cortical remodeling is most noticeable during the early stages, changes in brain activity continue until one year after injury. The processes of repair and reorganization of the central nervous system that begin soon after the injury, added to the physiotherapy rehabilitation intensified in the initial phase, will favor the learning or relearning the motor of the patient after the neuronal injury, because the rehabilitation process will happen at the peak of plasticity, thus favoring their motor responses. Several techniques have been used for the recovery of motor function, however there are controversies as to the result in neuroplasticity. The relationship between synaptic efficiency and microglial activation is still not well described in the literature. It is believed that during a specific task, the phagocytic activity of the microglia causes weaker synapses to be eliminated, leading to a greater activation of stronger synapses, thus, early physiotherapy in the early phase may promote the repair and healing process in the damaged areas, as well as, may favor the trophism and plasticity of the remaining neurons. Thus, this work aimed to review on neuro-glial interaction and neuronal plasticity, related to the aspects of early physiotherapy.


  1. Balasingan V., Tejada- T.,Wright E., Bouckowa R., Yong V. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci. 14, 846-56 (1994)
  2. Benvegnu AB, Gomes LA, Souza CT, Cuadros TBB, Pavão LW, Ãvila SN. Avaliação da medida de independência funcional de indivíduos com sequelas de acidente vascular encefálico (AVE). Revista Ciência & Saúde. 2008;1(2):71-77.
  3. Beuckmann C., Hellwig S., Galla H. Induction of the blood/brain-barrier-associated enzyme alcaline phosphatase in endotelial cells from cerebral capillaries in mediated via cAMP. Eur J Biomechem., 229, 641-44, 1995.
  4. Calautti C, Leroy F, Guincestre JY, Baron JC. Dynamics of motor network overactivation after striatocapsular stroke: a longitudinal PET study using a fixed-performance paradigm. Stroke 2001; 32:2534ñ2542
  5. Carr JH, Shepherd RB. Reabilitação Neurológica: Otimizando o Desempenho Motor. Acary Souza Bulle Oliveira et al. Barueri,SP: Manole Ltda, 2008, 369p.
  6. Chadi G, Cao Y, Pettersson RF, Fuxe K. Temporal and spatial increase of astroglial basic fibroblast growth factor synthesis after 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine neurons. Neuroscience 1994;61: 891-910.
  7. Cheatwood JL, Emerick AJ, Kartje GL. Neuronal plasticity and functional recovery after ischemic stroke. Top Stroke Rehabil 2008;15:42-50.
  8. David S., Bouchard C., Tsatas O., Giftochristos N. Macrophages can modify the no permissive nature of the adult mammalian central nervous system. Neuron, 5, 463-69, 1990.
  9. Dietz V. Neuronal plasticity after a human spinal cord injury: Positive and negative effects. Exp Neurol. 2012;235:110-5.
  10. Fawcett J. Astrocytes and axon regeneration in the central nervous system. J Neurol 1994;242: S25-8.
  11. Fouad K, Tetzlaff W. Rehabilitative training and plasticity following spinal cord injury. Exp Neurol. 2012;235:91-9.
  12. Gauthier LV, Taub E, Perkins C, Ortmann M, Mark VW, Uswatte G. Remodeling the brain: plastic structural brain changes produced by different motor therapies after stroke. Stroke 2008;39:1520-5.
  13. Giulian D, Li J, Leara B, Keenen C. Phagocytic micróglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture. Neurochem Int 1994;25: 227-33.
  14. Giulian D. Ameboid microglia as effectors of inflammation in the central nervous system. J Neurosci Res 1987;18: 155-71, 132-3.
  15. Giulian D., Baker T. Characterization of ameboid micróglia isolated from developing mammalian brain. J Neurosci, 6, 2163-78, 1986.
  16. Giulian D., Vaca K., Corpuz M. Brain glial release factors with opposing action upon neuronal survival. J Neurosci, 13, 29-37, 1993.
  17. Haruhiko A. Patrick L., McGeer. Microglial response to 6-hydroxydopamine-induced substantia nigra lesions. Brain Res, 489, 247-53, 1989.
  18. Johansen-Berg H, Matthews PM. Attention to movement modulates activity in sensori-motor areas, including primary motor cortex. Exp Brain Res 2002; 142:13-24
  19. Johansson, B. B. (2012). Multisensory stimulation in stroke rehabilitation. Frontiers in Human Neurosciense. Abril. Volume 6.Artigo 60, 1-11.
  20. Junqueira RT, Ribeiro AMB, Scianni AA. Efeitos do fortalecimento muscular e sua relação com a atividade funcional e a espasticidade em indivíduos hemiparéticos. Ver Bras Fisioter. 2004;8(3):247-252.
  21. Kao T, Shumsky JS, Murray M, Moxon KA. Exercise induces cortical plasticity after neonatal spinal cord injury in the rat. J Neurosci. 2009;29(23):7549-57.
  22. Konecny, P., Elfmark, M., Horak, S., Pastucha, D., Krobot, A., Urbanek, K., et al. (2014). Central facial paresis and its impact on mimicry, psyche and quality of live in pacients after stroke. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. Mar; 158, 133-137
  23. Kouji M., Hirofumi M., Norio O. Cyscloporin a attenuates the decrease in tirosina hydroxilase imunoreactivity in nigostriatal dopamine contente in rats with intrastriatal injection of 6-hydroxidopamine. Exp Neurol, 146, 526-35, 1997.
  24. Loubinoux I, Carel C, Pariente J, Dechaumont S, Albucher JF, Marque P, et al. Correlation between cerebral reorganization and motor recovery after subcortical infarcts. NeuroImage 2003;20(4):2166-2180.
  25. Marshall RS, Perera GM, Lazar RM, Krakauer JW, Constantine RC, Delapaz RL. Evolution of cortical activation during recovery from corticospinal tract infarction. Stroke. 2000;31:656-61.
  26. McCall M., Gregg R., Behringer R., Brenner M., Delaney c., Galbreath E., Zhang C., Pearce R., Chiu S., Messing A. Targeted deletion in astrocyte intemediated filamento (GFAP) alters neuronal physiology. Proc Natl Acad Sci USA, 93, 6361-66, 1996.
  27. McMillian M. K. Thai L., Kennedy M.K., O`Collanghan J.P., Pennypacker K.R. Brain injury in a dish: a model for reative gliosis. Trends Neurosci, 17, 138-42, 1994.
  28. Musienko P, Heutschi J, Friedli L, Van Den Brand R, Courtine G. Multi-system neurorehabilitative strategies to restore motor functions following severe spinal cord injury. Exp Neurol. 2012;235(1):100-9.
  29. Nadeau SE. A paradigm shift in neurorehabilitation. Lancet Neurol 2002;1: 126-130.
  30. Nudo, R. J. Adaptative plasticity in motor cortex: implications for rehabilitation after brain injury. J Rehabil Med, v. 41, n. 4, p. 7-10, 2003.
  31. Ogawa M., Araki M., Nagatsu I., Yoshida M. Astroglial cell alteration caused by neurotoxins: immunohistochemical observation with antibodies to glial fibrillary acidic protein, laminin and tyrosine hydroxylase. Exp Neurol., 106, 187-96, 1989.
  32. Oza CS, Giszter SF. Plasticity and alterations of trunk motor cortex following spinal cord injury and non-stepping robot and treadmill training. Exp Neurol. 2014;256:57-69.
  33. Perry V., Hume D., Gordon S. Immunohistochemical localization of macrophages and micróglia in the adult and developing mouse brain. Neuroscience, 15, 313-26, 1985.
  34. Reier P, J. Gliosis following CNS injury. IN: Vernadakis (ed). The anatomy of astrocytic scars and their influence on axonal elegantion. Orlando: Academic Press, 1986, pp.263-324.
  35. Rijntjes M, Weiller C. Recovery of motor and language abilities after stroke: the contribuition of functional imaging. Prog neurobiol. 2002; 66(2):109-122
  36. Rocca MA, Filippi M. Functional MRI to study brain plasticity in clinical neurology. Neurol Sci 2006;27:24-6.
  37. Rodrigues, A. C., Loureiro, M. A., & Caramelli, P. (2013). Long-term musical training may improve different forms of visual attention ability. Brain and Cognition 82, 229-235.
  38. Rodrigues, R. W. P.; Chadi G; Gomide, V.C Striatal injection of the 6¬Hydroxidopamine induces retrogade degeneration and glial activation in the nigrostriatal pathway. In: Acta Cirúrgica Brasileira. São Paulo: ,2003. v.18. p.272 ¬ 282
  39. Rodrigues, R. W. P.; Chadi G; Gomide, V.C Astroglial and Microglial reaction after a partial nigrostriatal degeneration induced by the striatal injection of In: International Journal Neuroscience. USA:, 2001. v.109. p.91 ¬ 126
  40. Rossini PM, Calauti C, Pauri F, Baron JC. Post-stroke plastic reorganization in the adult brain. Lancet Neurol 2003; 2:493-502.
  41. Rossini PM, Calauti C, Pauri F, Baron JC. Post-stroke plastic reorganization in the adult brain. Lancet Neurol 2003; 2:493-502.
  42. Rossini PM, Pauri F. Neuromagnetic integrated methods tracking human brain mechanisms of sensorimotor areas ëplasticí reorganisation. Brain Res Rev 2000; 33(2-3):131-154.
  43. RYERSON, S. Hemiplegia. In: UMPHRED, D. Reabilitação neurológica. 5. ed. Rio de Janeiro: Elsiever, p. 769-811, 2010.
  44. Schaechter JD. Motor rehabilitation and brain plasticity after hemiparetic stroke. Prog. neurobiol. 2004;73(1):61-72.
  45. Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, Stevens B. Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner. Neuron. 2012;74(4):691-705.
  46. Stinear CM, Barber PA, Coxon JP, Fleming MK, Byblow WD. Priming the motor system enhances the effects of upper limb therapy in chronic stroke. Brain 2008;131:1381-90.
  47. Streit WJ, Graeber MB Kreutzberg GW. Functional plasticity of microglia: a review. Glia 1988;1: 301-7.
  48. Stromberg I, Bjorklund H, Dahl D, Jonsson G, Sundstrom E, Olson L. Astrocyte responses to dopaminergic denervations by 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine as evidenced by glial fibrillary acidic protein immunohistochemistry. Brain Res Bull 1986;17: 225-36.
  49. Szaflarski JP, Page SJ, Kissela BM, Lee J, Levine P, Strakowski SM. Cortical Reorganization Following Modifed Constraint-Induced Movement Therepy: A Study of 4 Patients With Chronic Stroke. Arch Phys Med Rehabil 2006;87:1052 8.
  50. Teassel, R.; Bayona. N, A.; Bitensky, J. Plasticity and reorganization of brain post stroke. Top Stroke Rehab, v. 12, n. 3, p. 11-26, 2005.
  51. Thaut MH, Leins AK, Rice RR, Argstatter H, Kenyon GP, Mcintosh GC, et al. Rhythmic Auditory Stimulation Improves Gait More Than NDT/Bobath Training in NearAmbulatory Patients Early Poststroke: A Single-Blind, Randomized Trial.
  52. Neurorehabilitation and Neural Repair. 2007;21(5).
  53. The European Stroke Initiative Executive Committee and the EUSI Writing Committee. Cerebrovasc Dis, v. 16, p. 311-337, 2003.
  54. Thuret S, Moon LD, Gage FH. Therapeutic interventions after spinal cord injury. Nat Rev Neurosci. 2006;7(8):628-43.
  55. Tombari D, Loubinoux I, Pariente J, Gerdelat A, Albucher JF, Tardy J, et al. A longitudinal fMRI study: in recovery and then in clinically stable sub-cortical stroke patients. NeuroImage 2004; 23(3):827-839.
  56. Valente SCF, Paula EB, Abranches M, Costa V, Borges H, Chamlian TR, et al.
  57. Resultados da fisioterapia hospitalar na função do membro superior comprometido após acidente vascular encefálico. Rev Neurocienc. 2006;14(3):122-126.
  58. Vaynman SS, Gomez-Pinilla F. License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins. Neurorehab Neural Repair. 2005;19(4):283-95.
  59. Veerbeek, J. H., Wegen, E., Peppen, R., Wees, P. J., Hendriks, E., Rietberg, M., et al. (2014). What Is Evidence for Physical Therapy Poststroke? A Systematic Review and Meta-Analysis. Evidence for Physical Therapy Poststroke, 1-33
  60. Ward NS, Brown MM, Thompson AJ, Frackowiak RSJ. Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain 2003; 126(11):2476-2496.
  61. Ward NS, Brown MM, Thompson AJ, Frackowiak RSJ. Neural correlates of motor recovery after stroke: a longitudinal fMRI study. Brain 2003; 126(11):2476-2496
  62. Ward NS, Cohen LG. Mechanisms Underlying recovery of motor function after stroke. Arch Neurol 2004; 61(12):1844-1848.
  63. Ward NS. Functional reorganization of the cerebral motor system after stroke. Curr Opin Neurol 2004;17:725-30.

Como Citar

Rodrigues, R. W. P., Berber, G. C. M., & Berber, R. C. A. (2018). Effect of early physiotherapy on neuroglial interaction after injury to the motor cortex. Scientific Electronic Archives, 11(6), 107–114.