Co-processing Plant Extracts for Improvement of Their Pharmacotechnic Properties
DOI:
https://doi.org/10.36560/1120129Palavras-chave:
Espinheira Santa, effervescent granules, dry extractResumo
ABSTRACT: The herbal Espinheira Santa (Maytenus ilicifolia) can ingested in capsules for treatment of injuries from digestive tract, such as gastritis. However, the large amount of drug administered dose medication adherence difficult, so this study sought an alternative by formulating effervescent granules facilitating drug intake. The obtained granules made by wet and effervescent mixture of citric acid, sodium carbonate and sodium bicarbonate at different concentrations, totaling eight formulations, in addition to lactose as diluent and disintegrant in the composition. The granules were produced in sizes from 1 and 2mm. Rheological tests were compared against the dry extract, analyzed the average particle sizes of beads, mapped its surface by scanning electron microscopy and evaluated their behavior effervescent. The flow properties of the granules showed better values than the dry extract. The co-processed formulations showed average particle sizes distributed closed, where 1mm time effervescence had smaller, respecting all formulations, pharmacopeial limits of maximum 5 minutes. The preparation of effervescent granules Espinheira Santa proved to be a good alternativel, once that have easy preparation, low cost, excellent flow and rapid disintegration.
Keywords: Espinheira Santa, effervescent granules, dry extract.
Referências
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