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Ciências da Saúde
Publicado: 2024-04-30

Preliminary evaluation of the interaction with Albumin/DNA and in vitro evaluation of the antioxidant properties promoted by thiosemicarbazones and thiazole compounds

Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
antioxidante, macromoléculas, potencial biológico


Tiosemicarbazonas e tiazóis são conhecidos por suas diversas atividades biológicas. Este estudo introduziu duas séries de moléculas, 4-(3-(4-nitrofenil)-4-feniltiazol-2(3H)-ilideno)-hidrazina)-metil)-fenol e 4-(3-(4-clorofenil)- 4-feniltiazol-2(3H)-ilideno)-hidrazina)-metil)-fenol, que apresentam potencial biológico como agentes antioxidantes. O estudo também avaliou a interação desses compostos com diversas macromoléculas de HSA/DNA. Os resultados da atividade antioxidante mostraram que os tiazóis no ensaio DPPH exibiram valores de IC50 variando de 439,4 a 691,67 µM. No ensaio ABTS, as tiosemicarbazonas exibiram atividade significativa, variando de 39,19 a 50,03 µM. Os ensaios de interação foram realizados com albumina sérica humana (HSA) e DNA. Todos os compostos foram capazes de interagir tanto com DNA (interação baixa a moderada) quanto com HSA (interação moderada a alta).


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Como Citar

Nascimento, P. H. do B. ., Santos, K. L. dos ., Pereira, . A. V. L. A. ., Santos, J. C. B. dos ., Santa Clara Marques, D., Cruz Filho, I. J. da ., & Lima, M. do C. A. de . (2024). Preliminary evaluation of the interaction with Albumin/DNA and in vitro evaluation of the antioxidant properties promoted by thiosemicarbazones and thiazole compounds. Scientific Electronic Archives, 17(3).