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Scientific Electronic Archives
Health Science
DOI: 10.36560/17320241919
Submitted: 2024-03-17
Published: 2024-04-30

Preliminary evaluation of the interaction with Albumin/DNA and in vitro evaluation of the antioxidant properties promoted by thiosemicarbazones and thiazole compounds

Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
Federal University of Pernambuco
antioxidant, macromolecules, biological potential

Abstract

Thiosemicarbazones and thiazoles are known for their diverse biological activities. This study introduced two series of molecules, 4-(3-(4-nitrophenyl)-4-phenylthiazol-2(3H)-ylidene)-hydrazine)-methyl)-phenol and 4-(3-(4-chlorophenyl)-4-phenylthiazol-2(3H)-ylidene)-hydrazine)-methyl)-phenol, which exhibit biological potential as antioxidant agents. The study also assessed the interaction of these compounds with various HSA/DNA macromolecules. The results of the antioxidant activity showed that thiazoles in the DPPH assay exhibited IC50 values ranging from 439.4 to 691.67 µM. In the ABTS assay, thiosemicarbazones exhibited significant activity, ranging from 39.19 to 50.03 µM. Interaction assays were carried out with human serum albumin (HSA) and DNA. All compounds were able to interact with both DNA (low to moderate interaction) and HSA (moderate to high interaction).

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How to Cite

Nascimento, P. H. do B. ., Santos, K. L. dos ., Pereira, . A. V. L. A. ., Santos, J. C. B. dos ., Santa Clara Marques, D., Cruz Filho, I. J. da ., & Lima, M. do C. A. de . (2024). Preliminary evaluation of the interaction with Albumin/DNA and in vitro evaluation of the antioxidant properties promoted by thiosemicarbazones and thiazole compounds. Scientific Electronic Archives, 17(3). https://doi.org/10.36560/17320241919